Diphereline

Triptorelin (embonate) is an analogue of gonadotropin-releasing hormone (GnRH) and is the active component in Diphereline. GnRH is responsible for regulating the release of gonadotropins such as follicle stimulating hormone (FSH) and luteinizing hormone (LH) which in turn stimulate the gonads (reproductive organs; testes and ovaries). Upon stimulation the gonads produce the natural sex hormones testosterone (males) and estrogen (females).

Diphereline

Continuous stimulation of GnRH receptors as observed with Diphereline treatment results in the desensitisation of these receptors, eventually leading to a decrease in gonadotropin secretion. Thus, in males Diphereline treatment suppresses testicular function, lowering the production of testosterone. This is important because testosterone is thought to play a role in instigating cancer cell growth in some prostate cancer types. Therefore, by the reducing the levels of testosterone in males, Diphereline may be able lower and/or stop prostate cancer progression.

In Australia, Diphereline is indicated for:

  • The treatment of hormone-dependent locally advanced or metastatic prostate cancer.